The release date : Feb 06 2017　　　Browse the number : 1373

Plant Source Latin Name: Camellia sinensis

Spec : 30% Theaflavin

 

From Wikipedia, the free encyclopedia

Theaflavin
Names
IUPAC name 3,4,5-Trihydroxy-1,8-bis[(2R,3R)-3,5,7-trihydroxy-2-chromanyl]-6-benzo[7]annulenone
Identifiers
CAS Number	4670-05-7
Properties
Chemical formula	C29H24O12
Molar mass	564.50 g·mol−1
Except where otherwise noted, data are given for materials in their standard state(at 25 °C [77 °F], 100 kPa).

 

Theaflavin (TF) and its derivatives, known collectively as theaflavins, are antioxidant polyphenols that are formed from the condensation of flavan-3-olsin tea leaves during the enzymatic oxidation (sometimes erroneously referred to as fermentation) of black tea. Theaflavin-3-gallate, theaflavin-3'-gallate, theaflavin-3-3'-digallate are the main theaflavins. Theaflavins are types of thearubigins, and are therefore reddish in color. Epigallocatechin gallate (EGCG) will metabolize into some theaflavins in the liverThose molecules contain a tropolone moiety.

 

Research into health effects

HIV

In in vitro laboratory investigations, several tea polyphenols, especially those with galloyl moiety, can inhibit HIV-1 replication with multiple mechanisms of action. Theaflavin derivatives have been found to have more potent anti-HIV-1 activity than catechin derivatives.

Epigallocatechin gallate (EGCG), a catechin in green tea, binds to gp120, which works in conjunction with gp41, itself blocked by TF-3 (a theaflavin), both receptors of which HIV hijacks to enter into healthy human immune cells.

Cholesterol

In a human clinical trial published in 2003, theaflavins were found to reduce blood cholesterol levels, both total and LDL.

Cancer

In in vitro laboratory investigations, theaflavins have been found to act on numerous points regulating cancer cell growth, survival, and metastasis.For example, TF-3 is a potent scavenger of superoxide.